InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC9A3R2

Summary

InnateDB Protein

IDBP-364264.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC9A3R2

Protein Name

solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2

Synonyms

E3KARP; NHE3RF2; NHERF-2; NHERF2; OCTS2; SIP-1; SIP1; TKA-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000408005

InnateDB Gene

IDBG-9763 (SLC9A3R2)

Protein Structure

UniProt Annotation

Function

Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus. {ECO:0000269PubMed:10455146, ECO:0000269PubMed:9096337}.

Subcellular Localization

Endomembrane system {ECO:0000269PubMed:9054412}; Peripheral membrane protein {ECO:0000269PubMed:9054412}. Nucleus {ECO:0000269PubMed:9054412}. Apical cell membrane {ECO:0000250}. Note=Localizes with EZR and PODXL at the apical cell membrane of glomerular epithelium cells and the sides of the food processes (By similarity). Nuclear, in a punctate pattern. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:9054412, ECO:0000269PubMed:9096337}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	71 [view]
Protein-Protein	71 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008022	protein C-terminus binding
GO:0019902	phosphatase binding

Biological Process

GO:0006461	protein complex assembly
GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0012505	endomembrane system
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome