InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARRB2

Summary

InnateDB Protein

IDBP-362711.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARRB2

Protein Name

arrestin, beta 2

Synonyms

ARB2; ARR2; BARR2;

Species

Homo sapiens

Ensembl Protein

ENSP00000403701

InnateDB Gene

IDBG-19263 (ARRB2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 388 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	388 [view]
Protein-Protein	386 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0031625	ubiquitin protein ligase binding
GO:0031691	alpha-1A adrenergic receptor binding
GO:0031692	alpha-1B adrenergic receptor binding
GO:0031701	angiotensin receptor binding
GO:0031702	type 1 angiotensin receptor binding
GO:0031748	D1 dopamine receptor binding
GO:0031762	follicle-stimulating hormone receptor binding
GO:0031826	type 2A serotonin receptor binding
GO:0032403	protein complex binding
GO:0032947	protein complex scaffold
GO:0043422	protein kinase B binding
GO:0051019	mitogen-activated protein kinase binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0001932	regulation of protein phosphorylation
GO:0001934	positive regulation of protein phosphorylation
GO:0002031	G-protein coupled receptor internalization
GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin
GO:0002092	positive regulation of receptor internalization
GO:0006366	transcription from RNA polymerase II promoter
GO:0006897	endocytosis
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0007420	brain development
GO:0007596	blood coagulation
GO:0007628	adult walking behavior
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0015031	protein transport
GO:0016567	protein ubiquitination
GO:0030168	platelet activation
GO:0031397	negative regulation of protein ubiquitination
GO:0031398	positive regulation of protein ubiquitination
GO:0031623	receptor internalization
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032226	positive regulation of synaptic transmission, dopaminergic
GO:0032691	negative regulation of interleukin-1 beta production
GO:0032695	negative regulation of interleukin-12 production
GO:0032715	negative regulation of interleukin-6 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0034260	negative regulation of GTPase activity
GO:0034392	negative regulation of smooth muscle cell apoptotic process
GO:0042699	follicle-stimulating hormone signaling pathway
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045953	negative regulation of natural killer cell mediated cytotoxicity
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050965	detection of temperature stimulus involved in sensory perception of pain
GO:0051897	positive regulation of protein kinase B signaling
GO:0051928	positive regulation of calcium ion transport
GO:0060326	cell chemotaxis
GO:0060765	regulation of androgen receptor signaling pathway
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090201	negative regulation of release of cytochrome c from mitochondria
GO:2000573	positive regulation of DNA biosynthetic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0014069	postsynaptic density
GO:0016323	basolateral plasma membrane
GO:0030139	endocytic vesicle
GO:0031410	cytoplasmic vesicle
GO:0043197	dendritic spine
GO:0045211	postsynaptic membrane