InnateDB Protein
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IDBP-362338.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MBD3
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Protein Name
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methyl-CpG binding domain protein 3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000412302
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InnateDB Gene
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IDBG-14805 (MBD3)
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Protein Structure
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Function |
Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (PubMed:12124384). Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases. {ECO:0000269PubMed:10947852, ECO:0000269PubMed:12124384, ECO:0000269PubMed:18644863, ECO:0000269PubMed:23361464, ECO:0000269PubMed:24307175, ECO:0000269PubMed:9774669}.
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Subcellular Localization |
Nucleus. Chromosome. Note=Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated |
Total |
95
[view]
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Protein-Protein |
90
[view]
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Protein-DNA |
5
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
14 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001739
Methyl-CpG DNA binding
IPR016024
Armadillo-type fold
IPR016177
DNA-binding domain
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PFAM |
PF01429
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PRINTS |
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PIRSF |
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SMART |
SM00391
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TIGRFAMs |
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Modification |
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SwissProt |
O95983
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PhosphoSite |
PhosphoSite-O95983
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TrEMBL |
K7EIE8
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UniProt Splice Variant |
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Entrez Gene |
53615
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UniGene |
Hs.178728
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RefSeq |
NP_001268382
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HUGO |
HGNC:6918
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OMIM |
603573
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CCDS |
CCDS12072
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HPRD |
04653
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IMGT |
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EMBL |
AC005943
AF072247
AK001474
AK290882
BC009372
BC009438
BC032443
BC043619
CH471139
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GenPept |
AAC68876
AAC72104
AAH09372
AAH09438
AAH32443
AAH43619
BAF83571
BAG50920
EAW69477
EAW69478
EAW69479
EAW69481
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