InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TBC1D14

Summary

InnateDB Protein

IDBP-362025.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TBC1D14

Protein Name

TBC1 domain family, member 14

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000388886

InnateDB Gene

IDBG-9167 (TBC1D14)

Protein Structure

UniProt Annotation

Function

Negative regulator of starvation-induced autophagosome formation. {ECO:0000269PubMed:22613832}.

Subcellular Localization

Golgi apparatus, cis-Golgi network {ECO:0000269PubMed:22613832}. Golgi apparatus, trans-Golgi network {ECO:0000269PubMed:22613832}. Note=After amino acid starvation, Golgi apparatus-associated protein levels increase compared with fed conditions. May be cycling between the Golgi apparatus and an endosomal pool, redistributing to the Golgi apparatus upon starvation.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005097	Rab GTPase activator activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0010507	negative regulation of autophagy
GO:0032313	regulation of Rab GTPase activity
GO:0032851	positive regulation of Rab GTPase activity
GO:2000785	regulation of autophagic vacuole assembly