InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APP

Summary

InnateDB Protein

IDBP-361152.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APP

Protein Name

amyloid beta (A4) precursor protein

Synonyms

AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2;

Species

Homo sapiens

Ensembl Protein

ENSP00000396923

InnateDB Gene

IDBG-1100 (APP)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2628 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	2628 [view]
Protein-Protein	2625 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0008201	heparin binding
GO:0046914	transition metal ion binding

Biological Process

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR002223 Proteinase inhibitor I2, Kunitz metazoa
IPR008154 Amyloidogenic glycoprotein, extracellular
IPR008155 Amyloidogenic glycoprotein
IPR011178 Amyloidogenic glycoprotein, copper-binding
IPR015849 Amyloidogenic glycoprotein, heparin-binding
IPR024329 Amyloidogenic glycoprotein, E2 domain

PFAM

PF00014
PF12924
PF02177
PF12925

PRINTS

PR00759
PR00203

PIRSF

SMART

SM00131
SM00006

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt