InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APP

Summary

InnateDB Protein

IDBP-361148.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APP

Protein Name

amyloid beta (A4) precursor protein

Synonyms

AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2;

Species

Homo sapiens

Ensembl Protein

ENSP00000387483

InnateDB Gene

IDBG-1100 (APP)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2628 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	2628 [view]
Protein-Protein	2625 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0019899	enzyme binding
GO:0033130	acetylcholine receptor binding
GO:0042802	identical protein binding
GO:0046914	transition metal ion binding
GO:0051425	PTB domain binding

Biological Process

GO:0000085	mitotic G2 phase
GO:0002576	platelet degranulation
GO:0006378	mRNA polyadenylation
GO:0006417	regulation of translation
GO:0006468	protein phosphorylation
GO:0006878	cellular copper ion homeostasis
GO:0006897	endocytosis
GO:0007155	cell adhesion
GO:0007176	regulation of epidermal growth factor-activated receptor activity
GO:0007219	Notch signaling pathway
GO:0007409	axonogenesis
GO:0007596	blood coagulation
GO:0007617	mating behavior
GO:0007626	locomotory behavior
GO:0008088	axon cargo transport
GO:0008344	adult locomotory behavior
GO:0008542	visual learning
GO:0010951	negative regulation of endopeptidase activity
GO:0016199	axon midline choice point recognition
GO:0016322	neuron remodeling
GO:0016358	dendrite development
GO:0030168	platelet activation
GO:0030198	extracellular matrix organization
GO:0031175	neuron projection development
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0040014	regulation of multicellular organism growth
GO:0045087	innate immune response
GO:0045931	positive regulation of mitotic cell cycle
GO:0048669	collateral sprouting in absence of injury
GO:0050803	regulation of synapse structure and activity
GO:0051402	neuron apoptotic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005641	nuclear envelope lumen
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005905	coated pit
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0031093	platelet alpha granule lumen
GO:0043197	dendritic spine
GO:0043198	dendritic shaft
GO:0043231	intracellular membrane-bounded organelle
GO:0043235	receptor complex
GO:0045121	membrane raft
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002223 Proteinase inhibitor I2, Kunitz metazoa
IPR008154 Amyloidogenic glycoprotein, extracellular
IPR008155 Amyloidogenic glycoprotein
IPR011178 Amyloidogenic glycoprotein, copper-binding
IPR013803 Amyloidogenic glycoprotein, amyloid-beta peptide
IPR015849 Amyloidogenic glycoprotein, heparin-binding
IPR019543 Beta-amyloid precursor protein C-terminal
IPR024329 Amyloidogenic glycoprotein, E2 domain

PFAM

PF00014
PF12924
PF03494
PF02177
PF10515
PF12925

PRINTS

PR00759
PR00203
PR00204

PIRSF

SMART

SM00131
SM00006

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt