Version 5.4
Homo sapiens Protein: MN1
Summary
InnateDB Protein IDBP-3279.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MN1
Protein Name meningioma (disrupted in balanced translocation) 1
Synonyms dJ353E16.2; MGCR; MGCR1; MGCR1-PEN;
Species Homo sapiens
Ensembl Protein ENSP00000304956
InnateDB Gene IDBG-3277 (MN1)
Protein Structure
UniProt Annotation
Function May play a role in tumor suppression.
Subcellular Localization
Disease Associations Note=A chromosomal aberration involving MN1 may be a cause of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with TEL.Note=Defects in MN1 involved in the development of meningiomas, slowly growing benign tumors derived from the arachnoidal cap cells of the leptomeninges, the soft coverings of the brain and spinal cord. Meningiomas are believed to be the most common primary tumors of the central nervous system in man.
Tissue Specificity Ubiquitously expressed. Highest levels in skeletal muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0001957 intramembranous ossification
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q10571
PhosphoSite PhosphoSite-Q10571
TrEMBL A5HML1
UniProt Splice Variant
Entrez Gene 4330
UniGene Hs.618049
RefSeq NP_002421
HUGO HGNC:7180
OMIM 156100
CCDS CCDS42998
HPRD 08862
IMGT
EMBL AL031591 CH471095 EF540994 FO393416 X82209 Z70218
GenPept ABQ01232 CAA57693 CAA94179 EAW59741 EAW59742

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca