InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DYRK1A

Summary

InnateDB Protein

IDBP-3167.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DYRK1A

Protein Name

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

Synonyms

DYRK; DYRK1; HP86; MNB; MNBH; MRD7;

Species

Homo sapiens

Ensembl Protein

ENSP00000342690

InnateDB Gene

IDBG-3163 (DYRK1A)

Protein Structure

UniProt Annotation

Function

May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. {ECO:0000250, ECO:0000269PubMed:20981014, ECO:0000269PubMed:23665168, ECO:0000269PubMed:8769099}.

Subcellular Localization

Nucleus speckle.

Disease Associations

Mental retardation, autosomal dominant 7 (MRD7) [MIM:614104]: A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269PubMed:21294719}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney. {ECO:0000269PubMed:10329007, ECO:0000269PubMed:8769099, ECO:0000269PubMed:8872470, ECO:0000269PubMed:8975710}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	71 [view]
Protein-Protein	70 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0043621	protein self-association
GO:0048156	tau protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0007399	nervous system development
GO:0007623	circadian rhythm
GO:0018107	peptidyl-threonine phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0046777	protein autophosphorylation
GO:0090312	positive regulation of protein deacetylation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016607	nuclear speck

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt