InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BCL2L2

Summary

InnateDB Protein

IDBP-3159.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCL2L2

Protein Name

BCL2-like 2

Synonyms

BCL-W; BCL2-L-2; BCLW; PPP1R51;

Species

Homo sapiens

Ensembl Protein

ENSP00000250405

InnateDB Gene

IDBG-3157 (BCL2L2)

Protein Structure

UniProt Annotation

Function

Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. {ECO:0000269PubMed:8761287}.

Subcellular Localization

Mitochondrion membrane {ECO:0000269PubMed:11423909, ECO:0000269PubMed:12952938}; Peripheral membrane protein {ECO:0000269PubMed:11423909, ECO:0000269PubMed:12952938}. Note=Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.

Disease Associations

Tissue Specificity

Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines. {ECO:0000269PubMed:11423909}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0051400	BH domain binding

Biological Process

GO:0006915	apoptotic process
GO:0007283	spermatogenesis
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0060011	Sertoli cell proliferation
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005829	cytosol
GO:0031966	mitochondrial membrane
GO:0070062	extracellular vesicular exosome