InnateDB Protein
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IDBP-295047.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PDLIM2
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Protein Name
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PDZ and LIM domain 2 (mystique)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000386868
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InnateDB Gene
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IDBG-11055 (PDLIM2)
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Protein Structure
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Function |
Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269PubMed:15659642}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:15659642}. Nucleus {ECO:0000269PubMed:15659642}. Note=May be partially nuclear.Isoform 1: Cytoplasm, cytoskeleton. Note=Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN).Isoform 2: Cytoplasm, cytoskeleton.Isoform 3: Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001478
PDZ domain
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PFAM |
PF00595
PF13180
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PRINTS |
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PIRSF |
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SMART |
SM00228
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TIGRFAMs |
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Modification |
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SwissProt |
Q96JY6
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PhosphoSite |
PhosphoSite-Q96JY6
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TrEMBL |
C9K0F0
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UniProt Splice Variant |
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Entrez Gene |
64236
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UniGene |
Hs.632034
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RefSeq |
NP_932159
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HUGO |
HGNC:13992
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OMIM |
609722
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CCDS |
CCDS34861
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HPRD |
17831
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IMGT |
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EMBL |
AC037459
AF289563
AK024498
AK027800
AY007729
AY070438
AY217349
BC021556
BC071774
CH471080
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GenPept |
AAG16633
AAH21556
AAH71774
AAL55747
AAL65265
AAO45102
BAB15788
BAB55378
EAW63667
EAW63669
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