InnateDB Protein
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IDBP-294087.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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BLVRA
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Protein Name
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biliverdin reductase A
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Synonyms
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BLVR; BVR; BVRA;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000385757
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InnateDB Gene
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IDBG-13778 (BLVRA)
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Protein Structure
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Function |
Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.
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Subcellular Localization |
Cytoplasm.
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Disease Associations |
Hyperbiliverdinemia (HBLVD) [MIM:614156]: A condition characterized by a green discoloration of the skin, urine, serum, and other bodily fluids. It is due to increased biliverdin resulting from inefficient conversion to bilirubin. Affected individuals appear to have symptoms only in the context of obstructive cholestasis and/or liver failure. In some cases, green jaundice can resolve after resolution of obstructive cholestasis. {ECO:0000269PubMed:19580635}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Liver.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000683
Oxidoreductase, N-terminal
IPR015249
Biliverdin reductase, catalytic
IPR017094
Biliverdin reductase A
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PFAM |
PF01408
PF09166
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PRINTS |
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PIRSF |
PIRSF037032
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P53004
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PhosphoSite |
PhosphoSite-P53004
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TrEMBL |
C9J1E1
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UniProt Splice Variant |
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Entrez Gene |
644
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UniGene |
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RefSeq |
NP_001240752
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HUGO |
HGNC:1062
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OMIM |
109750
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CCDS |
CCDS5472
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HPRD |
11229
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IMGT |
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EMBL |
AC004939
AC004985
AC005189
AK291862
AY616754
BC005902
BC008456
U34877
X93086
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GenPept |
AAC35588
AAD05025
AAH05902
AAH08456
AAP21879
AAT11126
BAF84551
CAA63635
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