Version 5.4
Homo sapiens Protein: URGCP
Summary
InnateDB Protein IDBP-294072.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol URGCP
Protein Name upregulator of cell proliferation
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000384955
InnateDB Gene IDBG-13865 (URGCP)
Protein Structure
UniProt Annotation
Function May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer. {ECO:0000269PubMed:12082552, ECO:0000269PubMed:17217616}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:12082552, ECO:0000269PubMed:17217616}. Nucleus {ECO:0000269PubMed:12082552, ECO:0000269PubMed:17217616}. Note=In epithelial cells localized predominantly in the cytoplasm and occasionally in nuclei.
Disease Associations
Tissue Specificity Strongly expressed in hepatitis B virus- infected liver and in HCC cells. Also highly expressed in well- differentiated gastric cancer tissues and various gastric cancer cell lines. {ECO:0000269PubMed:12082552, ECO:0000269PubMed:17217616}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005525 GTP binding
Biological Process
GO:0007049 cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR006073 GTP binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF01926
PRINTS PR00326
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TCY9
PhosphoSite PhosphoSite-Q8TCY9
TrEMBL C9JKA8
UniProt Splice Variant
Entrez Gene 55665
UniGene Hs.663312
RefSeq NP_060390
HUGO HGNC:30890
OMIM 610337
CCDS CCDS47577
HPRD 11663
IMGT
EMBL AB040940 AC004985 AK000661 AL833744 AY078404 BC018426 BX640797 CH471073 CR749398
GenPept AAH18426 AAL83710 BAA91312 BAA96031 CAE45880 CAH18244 CAH56246 EAW94174 EAW94176

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca