InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIOBP

Summary

InnateDB Protein

IDBP-293779.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIOBP

Protein Name

TRIO and F-actin binding protein

Synonyms

DFNB28; dJ37E16.4; TAP68; TARA;

Species

Homo sapiens

Ensembl Protein

ENSP00000384312

InnateDB Gene

IDBG-6969 (TRIOBP)

Protein Structure

UniProt Annotation

Function

May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover. {ECO:0000269PubMed:18194665}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9853615}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:9853615}. Note=Localized to F-actin in a periodic pattern.Isoform 1: Nucleus {ECO:0000269PubMed:22820163}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:22820163}. Midbody {ECO:0000269PubMed:22820163}. Note=Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-457 and lasts from prophase to anaphase. At telophase, relocalizes to midbody.

Disease Associations

Deafness, autosomal recessive, 28 (DFNB28) [MIM:609823]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269PubMed:16385457, ECO:0000269PubMed:16385458}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed. Highly expressed in heart and placenta. Isoform 3 is expressed in fetal brain, retina and cochlea but is not detectable in the other tissues. {ECO:0000269PubMed:16385458}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0017049	GTP-Rho binding
GO:0031625	ubiquitin protein ligase binding
GO:0045159	myosin II binding
GO:0051015	actin filament binding

Biological Process

GO:0007067	mitotic nuclear division
GO:0030047	actin modification
GO:0051016	barbed-end actin filament capping
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading