InnateDB Protein
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IDBP-292706.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ID2
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Protein Name
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inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
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Synonyms
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bHLHb26; GIG8; ID2A; ID2H;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000385465
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InnateDB Gene
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IDBG-27111 (ID2)
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Protein Structure
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Function |
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. {ECO:0000269PubMed:20861012}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:20861012}. Nucleus {ECO:0000255PROSITE-ProRule:PRU00981, ECO:0000269PubMed:20861012}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in early fetal tissues, including those of the central nervous system.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated |
Total |
49
[view]
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Protein-Protein |
49
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
13 [view]
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Molecular Function |
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Biological Process |
GO:0007275
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multicellular organismal development
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GO:0010628
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positive regulation of gene expression
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GO:0010629
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negative regulation of gene expression
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GO:0019216
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regulation of lipid metabolic process
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GO:0032922
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circadian regulation of gene expression
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GO:0033598
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mammary gland epithelial cell proliferation
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GO:0042752
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regulation of circadian rhythm
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GO:0043153
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entrainment of circadian clock by photoperiod
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GO:0043433
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negative regulation of sequence-specific DNA binding transcription factor activity
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GO:0045475
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locomotor rhythm
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GO:0045665
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negative regulation of neuron differentiation
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GO:0045777
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positive regulation of blood pressure
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0048557
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embryonic digestive tract morphogenesis
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GO:0048661
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positive regulation of smooth muscle cell proliferation
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GO:0048663
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neuron fate commitment
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GO:0060749
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mammary gland alveolus development
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GO:0061030
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epithelial cell differentiation involved in mammary gland alveolus development
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GO:0061031
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endodermal digestive tract morphogenesis
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GO:0071158
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positive regulation of cell cycle arrest
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GO:0071931
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positive regulation of transcription involved in G1/S transition of mitotic cell cycle
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GO:0090398
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cellular senescence
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GO:2000045
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regulation of G1/S transition of mitotic cell cycle
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GO:2000178
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negative regulation of neural precursor cell proliferation
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Cellular Component |
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PDB ID |
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InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
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PFAM |
PF00010
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PRINTS |
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PIRSF |
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
Q02363
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PhosphoSite |
PhosphoSite-Q02363
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TrEMBL |
Q53T66
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UniProt Splice Variant |
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Entrez Gene |
3398
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UniGene |
Hs.665350
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RefSeq |
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HUGO |
HGNC:5361
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OMIM |
600386
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CCDS |
CCDS1659
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HPRD |
02664
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IMGT |
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EMBL |
AC011747
AK311988
AY634687
BC030639
CH471053
D13891
M97796
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GenPept |
AAA58681
AAH30639
AAV35470
AAY14810
BAA02990
BAG34927
EAX01018
EAX01019
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