Version 5.4
Homo sapiens Protein: WIPI2
Summary
InnateDB Protein IDBP-292607.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WIPI2
Protein Name WD repeat domain, phosphoinositide interacting 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000384945
InnateDB Gene IDBG-7422 (WIPI2)
Protein Structure
UniProt Annotation
Function Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P. {ECO:0000269PubMed:20505359}.
Subcellular Localization Preautophagosomal structure membrane {ECO:0000269PubMed:20505359, ECO:0000269PubMed:21564513, ECO:0000269PubMed:22456507}; Peripheral membrane protein {ECO:0000269PubMed:20505359, ECO:0000269PubMed:21564513, ECO:0000269PubMed:22456507}; Cytoplasmic side {ECO:0000269PubMed:20505359, ECO:0000269PubMed:21564513, ECO:0000269PubMed:22456507}. Note=Enriched at preautophagosomal structure membranes in response to ptdIns3P.
Disease Associations
Tissue Specificity Ubiquitously expressed (at protein level). Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors. {ECO:0000269PubMed:15602573, ECO:0000269PubMed:20505359}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding
Biological Process
GO:0000045 autophagic vacuole assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005776 autophagic vacuole
GO:0005829 cytosol
GO:0034045 pre-autophagosomal structure membrane
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y4P8
PhosphoSite PhosphoSite-Q9Y4P8
TrEMBL
UniProt Splice Variant
Entrez Gene 26100
UniGene Hs.700671
RefSeq NP_057087
HUGO HGNC:32225
OMIM 609225
CCDS CCDS34593
HPRD 15679
IMGT
EMBL AC093376 AF151808 AK024279 AL080155 AY691425 AY691426 BC004116 BC007596 BC021068 BC021200 CH471144 CR533530
GenPept AAD34045 AAH04116 AAH07596 AAH21200 AAQ96865 AAQ96866 AAQ96867 AAV80761 AAV80762 BAG51284 CAB45746 CAG38561 EAW87328

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca