InnateDB Protein
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IDBP-292531.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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COMT
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Protein Name
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catechol-O-methyltransferase
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Synonyms
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HEL-S-98n;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000384654
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InnateDB Gene
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IDBG-1506 (COMT)
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Protein Structure
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Function |
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
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Subcellular Localization |
Isoform Soluble: Cytoplasm.Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side.
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Disease Associations |
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Tissue Specificity |
Brain, liver, placenta, lymphocytes and erythrocytes.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002935
O-methyltransferase, family 3
IPR017128
Catechol O-methyltransferase, eukaryotic
IPR029063
S-adenosyl-L-methionine-dependent methyltransferase-like
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PFAM |
PF01596
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PRINTS |
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PIRSF |
PIRSF037177
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P21964
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PhosphoSite |
PhosphoSite-P21964
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TrEMBL |
Q7KZP0
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UniProt Splice Variant |
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Entrez Gene |
1312
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UniGene |
Hs.370408
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RefSeq |
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HUGO |
HGNC:2228
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OMIM |
116790
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CCDS |
CCDS13770
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HPRD |
00284
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IMGT |
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EMBL |
AC000080
AC000090
AC005663
AK290440
AY341246
BC011935
BC100018
BT007125
CH471176
CR456422
CR456997
HQ262572
HQ262573
M58525
M65212
M65213
Z26491
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GenPept |
AAA68927
AAA68928
AAA68929
AAH11935
AAI00019
AAP35789
AAP88929
AEA30239
AEA30240
BAF83129
CAA81263
CAG30308
CAG33278
EAX03010
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