InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: INTS1

Summary

InnateDB Protein

IDBP-292482.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INTS1

Protein Name

integrator complex subunit 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000385722

InnateDB Gene

IDBG-6535 (INTS1)

Protein Structure

UniProt Annotation

Function

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.

Subcellular Localization

Nucleus membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding

Biological Process

GO:0001832	blastocyst growth
GO:0001833	inner cell mass cell proliferation
GO:0016180	snRNA processing
GO:0034474	U2 snRNA 3'-end processing
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process