InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADORA2A

Summary

InnateDB Protein

IDBP-2847.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADORA2A

Protein Name

adenosine A2a receptor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000336630

InnateDB Gene

IDBG-2843 (ADORA2A)

Protein Structure

UniProt Annotation

Function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001609	G-protein coupled adenosine receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0042802	identical protein binding

Biological Process

GO:0006171	cAMP biosynthetic process
GO:0006909	phagocytosis
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0006968	cellular defense response
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007267	cell-cell signaling
GO:0007417	central nervous system development
GO:0007596	blood coagulation
GO:0007600	sensory perception
GO:0008015	blood circulation
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0048011	neurotrophin TRK receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001513 Adenosine A2A receptor
IPR001634 Adenosine receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00553
PR00424

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P29274