Version 5.4
Homo sapiens Protein: CYP11A1
Summary
InnateDB Protein IDBP-28460.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP11A1
Protein Name cytochrome P450, family 11, subfamily A, polypeptide 1
Synonyms CYP11A; CYPXIA1; P450SCC;
Species Homo sapiens
Ensembl Protein ENSP00000351455
InnateDB Gene IDBG-21987 (CYP11A1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
Biological Process
GO:0006700 C21-steroid hormone biosynthetic process
GO:0006805 xenobiotic metabolic process
GO:0008202 steroid metabolic process
GO:0008203 cholesterol metabolic process
GO:0016125 sterol metabolic process
GO:0042359 vitamin D metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID
InterPro IPR001128 Cytochrome P450
IPR002397 Cytochrome P450, B-class
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
PFAM PF00067
PRINTS PR00385
PR00359
PR00463
PR00465
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P05108
PhosphoSite PhosphoSite-P05108
TrEMBL Q2HZF3
UniProt Splice Variant
Entrez Gene 1583
UniGene Hs.303980
RefSeq NP_001093243
HUGO HGNC:2590
OMIM 118485
CCDS CCDS45303
HPRD 00326
IMGT
EMBL AC090826 AK056794 AK292300 BC032329 CH471136 DQ358147 M14565 M28253 X05367 X05368 X05369 X05370 X05371 X05372 X05373 X05374 X14257
GenPept AAA36404 AAA52162 AAH32329 ABC86898 BAF84989 BAG51810 CAA28965 CAA32471 EAW99341 EAW99342

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca