InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PIK3C3

Summary

InnateDB Protein

IDBP-2713.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIK3C3

Protein Name

phosphoinositide-3-kinase, class 3

Synonyms

hVps34; VPS34;

Species

Homo sapiens

Ensembl Protein

ENSP00000262039

InnateDB Gene

IDBG-2711 (PIK3C3)

Protein Structure

UniProt Annotation

Function

Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes. {ECO:0000269PubMed:14617358, ECO:0000269PubMed:20208530, ECO:0000269PubMed:7628435}.

Subcellular Localization

Midbody. Late endosome. Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed, with a highest expression in skeletal muscle. {ECO:0000269PubMed:7628435}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	50 [view]
Protein-Protein	47 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016303	1-phosphatidylinositol-3-kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0035004	phosphatidylinositol 3-kinase activity

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0000910	cytokinesis
GO:0002224	toll-like receptor signaling pathway
GO:0006468	protein phosphorylation
GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0007032	endosome organization
GO:0008286	insulin receptor signaling pathway
GO:0016485	protein processing
GO:0034162	toll-like receptor 9 signaling pathway
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
GO:0043201	response to leucine
GO:0044281	small molecule metabolic process
GO:0045022	early endosome to late endosome transport
GO:0045087	innate immune response (InnateDB)
GO:0046854	phosphatidylinositol phosphorylation
GO:0048015	phosphatidylinositol-mediated signaling
GO:0050708	regulation of protein secretion

Cellular Component

GO:0005770	late endosome
GO:0005829	cytosol
GO:0005930	axoneme
GO:0005942	phosphatidylinositol 3-kinase complex
GO:0016020	membrane
GO:0030496	midbody
GO:0045335	phagocytic vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR002420 Phosphatidylinositol 3-kinase, C2 domain
IPR008290 Phosphatidylinositol 3-kinase, Vps34 type
IPR011009 Protein kinase-like domain
IPR016024 Armadillo-type fold

PFAM

PF00168
PF00454
PF00613
PF00792

PRINTS

PR00360

PIRSF

PIRSF000587

SMART

SM00239
SM00146
SM00145
SM00142

TIGRFAMs

Post-translational Modifications

Modification

Cross-References