InnateDB Protein
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IDBP-271065.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Mbd3
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Protein Name
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methyl-CpG binding domain protein 3
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Synonyms
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AI181826; AU019209;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000100986
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InnateDB Gene
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IDBG-174078 (Mbd3)
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Protein Structure
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Function |
Acts as transcriptional repressor and plays a role in gene silencing. Does not bind DNA by itself. Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (By similarity). Recruits histone deacetylases and DNA methyltransferases. {ECO:0000250, ECO:0000269PubMed:9774669}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:14610093, ECO:0000269PubMed:9774669}. Chromosome {ECO:0000250}. Note=Detected on chromatin, at promoter regions of active genes (By similarity). Nuclear, in discrete foci. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in brain, heart, kidney, liver, lung, skeletal muscle, spleen and testis. Detected at lower levels in embryonic stem cells. {ECO:0000269PubMed:9774669}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Experimentally validated |
Total |
28
[view]
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Protein-Protein |
28
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
50 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1333812
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InterPro |
IPR001739
Methyl-CpG DNA binding
IPR016177
DNA-binding domain
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PFAM |
PF01429
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PRINTS |
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PIRSF |
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SMART |
SM00391
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Z2D8
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PhosphoSite |
PhosphoSite-Q9Z2D8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
17192
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UniGene |
Mm.7142
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RefSeq |
XP_006513367
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MGI ID |
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MGI Symbol |
Mbd3
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AF072248
AF120995
BC038264
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GenPept |
AAC68877
AAD48909
AAH38264
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