Version 5.4
Homo sapiens Protein: SLC5A3
Summary
InnateDB Protein IDBP-2689.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC5A3
Protein Name solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
Synonyms BCW2; SMIT; SMIT1; SMIT2;
Species Homo sapiens
Ensembl Protein ENSP00000370543
InnateDB Gene IDBG-2685 (SLC5A3)
Protein Structure
UniProt Annotation
Function Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005367 myo-inositol:sodium symporter activity
GO:0005524 ATP binding
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
Biological Process
GO:0006020 inositol metabolic process
GO:0006810 transport
GO:0006814 sodium ion transport
GO:0007422 peripheral nervous system development
GO:0015798 myo-inositol transport
GO:0043576 regulation of respiratory gaseous exchange
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001734 Sodium/solute symporter
IPR011527 ABC transporter type 1, transmembrane domain
IPR019900 Sodium/solute symporter, subgroup
PFAM PF00474
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P53794
PhosphoSite PhosphoSite-P53794
TrEMBL
UniProt Splice Variant
Entrez Gene 6526
UniGene Hs.710797
RefSeq NP_008864
HUGO HGNC:11038
OMIM 600444
CCDS CCDS33549
HPRD 02708
IMGT
EMBL AF027153 AP001719 L38500
GenPept AAC39548 AAC41747

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca