InnateDB Protein
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IDBP-268676.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Polr3e
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Protein Name
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polymerase (RNA) III (DNA directed) polypeptide E
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Synonyms
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RPC5; Sin;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000102092
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InnateDB Gene
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IDBG-208615 (Polr3e)
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Protein Structure
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Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific periphjeric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
12 [view]
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Molecular Function |
Accession |
GO Term |
GO:0001056
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RNA polymerase III activity
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GO:0003899
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DNA-directed RNA polymerase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1349452
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InterPro |
IPR006886
DNA-directed RNA polymerase III subunit Rpc5
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PFAM |
PF04801
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9CZT4
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PhosphoSite |
PhosphoSite-Q9CZT4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
26939
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UniGene |
Mm.193632
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RefSeq |
NP_001157568
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MGI ID |
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MGI Symbol |
Polr3e
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OMIM |
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CCDS |
CCDS52383
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HPRD |
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IMGT |
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EMBL |
AK005034
AK012184
BC037637
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GenPept |
AAH37637
BAB23761
BAB28084
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