InnateDB Protein
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IDBP-261850.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Triobp
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Protein Name
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TRIO and F-actin binding protein
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Synonyms
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AI428493; EST478828; mKIAA1662; Tara;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000105312
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InnateDB Gene
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IDBG-160440 (Triobp)
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Protein Structure
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Function |
May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized to F-actin in a periodic pattern. {ECO:0000250}.Isoform 1: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Midbody {ECO:0000250}. Note=Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-445 and lasts from prophase to anaphase. At telophase, relocalizes to midbody (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
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Biological Process |
GO:0007067
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mitotic nuclear division
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GO:1900026
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positive regulation of substrate adhesion-dependent cell spreading
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Cellular Component |
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PDB ID |
MGI:1349410
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InterPro |
IPR001849
Pleckstrin homology domain
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PFAM |
PF00169
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PRINTS |
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PIRSF |
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SMART |
SM00233
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TIGRFAMs |
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Modification |
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SwissProt |
Q99KW3
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PhosphoSite |
PhosphoSite-Q99KW3
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TrEMBL |
J9JI90
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UniProt Splice Variant |
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Entrez Gene |
110253
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UniGene |
Mm.123714
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RefSeq |
NP_001034245
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MGI ID |
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MGI Symbol |
Triobp
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OMIM |
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CCDS |
CCDS37136
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HPRD |
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IMGT |
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EMBL |
AK053194
AK129417
AK170390
AL589670
BC003984
BC042760
BC053329
DQ228000
DQ228001
DQ228002
DQ278602
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GenPept |
AAH03984
AAH42760
AAH53329
ABB59556
ABB59557
ABB59558
ABB77203
BAC35308
BAC98227
BAE41764
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