InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hnrnpc

Summary

InnateDB Protein

IDBP-257749.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hnrnpc

Protein Name

heterogeneous nuclear ribonucleoprotein C

Synonyms

AL022939; D14Wsu171e; hnrnp-C; hnRNPC1; hnRNPC2; Hnrpc; Hnrpc1; Hnrpc2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107237

InnateDB Gene

IDBG-158143 (Hnrnpc)

Protein Structure

UniProt Annotation

Function

Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Component of ribonucleosomes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 121 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	121 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003676	nucleic acid binding
GO:0003729	mRNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0005515	protein binding
GO:0008266	poly(U) RNA binding
GO:0031492	nucleosomal DNA binding
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0043044	ATP-dependent chromatin remodeling
GO:0070935	3'-UTR-mediated mRNA stabilization

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005829	cytosol
GO:0016020	membrane
GO:0043234	protein complex
GO:0045120	pronucleus
GO:0070062	extracellular vesicular exosome
GO:0071013	catalytic step 2 spliceosome