InnateDB Protein
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IDBP-256774.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Clec7a
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Protein Name
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C-type lectin domain family 7, member a
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000107707
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InnateDB Gene
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IDBG-256772 (Clec7a)
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Protein Structure
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Function |
Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. {ECO:0000269PubMed:10779524, ECO:0000269PubMed:11544516, ECO:0000269PubMed:12719479, ECO:0000269PubMed:15213161, ECO:0000269PubMed:15729357, ECO:0000269PubMed:15731053, ECO:0000269PubMed:15845454, ECO:0000269PubMed:16825490}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:10779524, ECO:0000269PubMed:15213161}; Single-pass type II membrane protein {ECO:0000269PubMed:10779524, ECO:0000269PubMed:15213161}. Note=Enriched on zymosan phagosomes. Enrichment does not depend on opsonization.
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Disease Associations |
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Tissue Specificity |
Detected in spleen (at protein level). Highly expressed in dendritic cells, spleen and thymus. Detected in epidermal Langerhans cells. Detected in macrophages, liver and lung. {ECO:0000269PubMed:10779524, ECO:0000269PubMed:11544516, ECO:0000269PubMed:12719479}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1861431
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InterPro |
IPR001304
C-type lectin
IPR002353
Type-2 ice-structuring protein
IPR016187
C-type lectin fold
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PFAM |
PF00059
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PRINTS |
PR00356
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PIRSF |
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SMART |
SM00034
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TIGRFAMs |
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Modification |
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SwissProt |
Q6QLQ4
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
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UniGene |
Mm.239516
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RefSeq |
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MGI ID |
2CL8
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MGI Symbol |
Clec7a
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AC138620
AF262985
AY534909
BC027742
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GenPept |
AAF72710
AAH27742
AAS37670
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