InnateDB Protein
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IDBP-255712.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Nanog
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Protein Name
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Nanog homeobox
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Synonyms
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2410002E02Rik; ecat4; ENK;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000108200
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InnateDB Gene
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IDBG-185735 (Nanog)
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Protein Structure
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Function |
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'- [CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. {ECO:0000269PubMed:12787504, ECO:0000269PubMed:12787505, ECO:0000269PubMed:14728807, ECO:0000269PubMed:15502159, ECO:0000269PubMed:16518401, ECO:0000269PubMed:16791199, ECO:0000269PubMed:16801560, ECO:0000269PubMed:21915945, ECO:0000269PubMed:22988117}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000269PubMed:15582778}.
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Disease Associations |
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Tissue Specificity |
Not expressed in oocytes and spermatogonia (at protein level). Not expressed in many somatic organs, ovary, testis, fibroblast and hematopoietic cell lines. {ECO:0000269PubMed:12787504, ECO:0000269PubMed:12787505, ECO:0000269PubMed:15108323, ECO:0000269PubMed:15939376}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 288 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
288
[view]
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Protein-Protein |
278
[view]
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Protein-DNA |
10
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1919200
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InterPro |
IPR001356
Homeobox domain
IPR009057
Homeodomain-like
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PFAM |
PF00046
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PRINTS |
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PIRSF |
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SMART |
SM00389
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TIGRFAMs |
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Modification |
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SwissProt |
Q80Z64
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PhosphoSite |
PhosphoSite-Q80Z64
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
71950
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UniGene |
Mm.6047
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RefSeq |
NP_001276760
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MGI ID |
2VI6
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MGI Symbol |
Nanog
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AB093574
AF507043
AK010332
AY278951
AY455282
AY455285
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GenPept |
AAO67362
AAP92157
AAS57554
AAS57556
BAC76998
BAE43219
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