Version 5.4
Mus musculus Protein: Slc5a3
Summary
InnateDB Protein IDBP-252757.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc5a3
Protein Name solute carrier family 5 (inositol transporters), member 3
Synonyms AA623876; BF642829; Smit1;
Species Mus musculus
Ensembl Protein ENSMUSP00000109608
InnateDB Gene IDBG-488319 (Slc5a3)
Protein Structure
UniProt Annotation
Function Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function. {ECO:0000269PubMed:12719585}.Functions as a retroviral receptor for M813 murine leukemia virus (MuLV) entry. {ECO:0000269PubMed:12719585}.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0015293 symporter activity
Biological Process
GO:0006020 inositol metabolic process
GO:0006810 transport
GO:0006814 sodium ion transport
GO:0007422 peripheral nervous system development
GO:0015798 myo-inositol transport
GO:0043576 regulation of respiratory gaseous exchange
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1858226
InterPro IPR001734 Sodium/solute symporter
IPR019900 Sodium/solute symporter, subgroup
PFAM PF00474
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JKZ2
PhosphoSite PhosphoSite-Q9JKZ2
TrEMBL V9GXD5
UniProt Splice Variant
Entrez Gene 53881
UniGene Mm.455912
RefSeq NP_059087
MGI ID
MGI Symbol Slc5a3
OMIM
CCDS CCDS37403
HPRD
IMGT
EMBL AC144408 AF220915 AK144718 BC140982 BC140983 CH466602
GenPept AAF43668 AAI40983 AAI40984 BAE26029 EDL03793

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca