InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLDN3

Summary

InnateDB Protein

IDBP-240165.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLDN3

Protein Name

claudin 3

Synonyms

C7orf1; CPE-R2; CPETR2; HRVP1; RVP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000378577

InnateDB Gene

IDBG-20433 (CLDN3)

Protein Structure

UniProt Annotation

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. {ECO:0000250}.

Subcellular Localization

Cell junction, tight junction {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Note=CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	6 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0001666	response to hypoxia
GO:0007165	signal transduction
GO:0016338	calcium-independent cell-cell adhesion

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0005923	tight junction
GO:0016021	integral component of membrane
GO:0016328	lateral plasma membrane
GO:0070062	extracellular vesicular exosome