InnateDB Protein
|
IDBP-239340.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
COBL
|
Protein Name
|
cordon-bleu homolog (mouse)
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000378910
|
InnateDB Gene
|
IDBG-16785 (COBL)
|
Protein Structure
|
|
Function |
Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269PubMed:21816349}.
|
Subcellular Localization |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Recruited to the cell membrane via interaction with PACSIN1. Colocalizes with the actin cytoskeleton. Detected throughout the neuron cell body, as well as in axons and dendrites (By similarity). {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
|
Protein-Protein |
5
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0003785
|
actin monomer binding
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR019025
Cordon-bleu, ubiquitin-like domain
IPR029071
Ubiquitin-related domain
|
PFAM |
PF09469
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O75128
|
PhosphoSite |
PhosphoSite-O75128
|
TrEMBL |
C9J9X1
|
UniProt Splice Variant |
|
Entrez Gene |
23242
|
UniGene |
Hs.99141
|
RefSeq |
|
HUGO |
HGNC:22199
|
OMIM |
610317
|
CCDS |
|
HPRD |
10843
|
IMGT |
|
EMBL |
AB014533
AC004414
AC005535
AC012372
AL713786
BC029275
BC045771
BC094695
BC111496
BC136441
BC144099
BC150263
CH236955
CH471128
|
GenPept |
AAH29275
AAH45771
AAH94695
AAI11497
AAI36442
AAI44100
AAI50264
BAA31608
CAD28543
EAL23896
EAW60962
|
|
|