InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ERO1L

Summary

InnateDB Protein

IDBP-239035.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERO1L

Protein Name

ERO1-like (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000379042

InnateDB Gene

IDBG-6806 (ERO1L)

Protein Structure

UniProt Annotation

Function

Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. {ECO:0000269PubMed:10671517, ECO:0000269PubMed:10970843, ECO:0000269PubMed:11707400, ECO:0000269PubMed:12403808, ECO:0000269PubMed:18833192, ECO:0000269PubMed:18971943, ECO:0000269PubMed:23027870}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:10671517, ECO:0000269PubMed:14517240}; Peripheral membrane protein {ECO:0000269PubMed:10671517, ECO:0000269PubMed:14517240}; Lumenal side {ECO:0000269PubMed:10671517, ECO:0000269PubMed:14517240}. Note=The association with ERP44 is essential for its retention in the endoplasmic reticulum.

Disease Associations

Tissue Specificity

Widely expressed at low level. Expressed at high level in upper digestive tract. Highly expressed in esophagus. Weakly expressed in stomach and duodenum. {ECO:0000269PubMed:10818100}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003756	protein disulfide isomerase activity
GO:0005515	protein binding
GO:0015035	protein disulfide oxidoreductase activity
GO:0016491	oxidoreductase activity
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

Biological Process

GO:0006457	protein folding
GO:0006464	cellular protein modification process
GO:0009266	response to temperature stimulus
GO:0019471	4-hydroxyproline metabolic process
GO:0022417	protein maturation by protein folding
GO:0030198	extracellular matrix organization
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0034976	response to endoplasmic reticulum stress
GO:0044267	cellular protein metabolic process
GO:0045454	cell redox homeostasis
GO:0050873	brown fat cell differentiation
GO:0051085	chaperone mediated protein folding requiring cofactor
GO:0051209	release of sequestered calcium ion into cytosol
GO:0055114	oxidation-reduction process
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle