Version 5.4
Homo sapiens Protein: PPP6R2
Summary
InnateDB Protein IDBP-238910.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP6R2
Protein Name protein phosphatase 6, regulatory subunit 2
Synonyms KIAA0685; PP6R2; SAP190; SAPS2;
Species Homo sapiens
Ensembl Protein ENSP00000379090
InnateDB Gene IDBG-13286 (PPP6R2)
Protein Structure
UniProt Annotation
Function Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6- mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. {ECO:0000269PubMed:16769727}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16769727}.
Disease Associations
Tissue Specificity Ubiquitously expressed with strongest expression in the testis followed by liver, heart, kidney, brain and placenta. {ECO:0000269PubMed:16769727}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
Experimentally validated
Total 48 [view]
Protein-Protein 48 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR007587 SIT4 phosphatase-associated protein family
IPR016024 Armadillo-type fold
PFAM PF04499
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75170
PhosphoSite PhosphoSite-O75170
TrEMBL
UniProt Splice Variant
Entrez Gene 9701
UniGene Hs.729287
RefSeq NP_001229828
HUGO HGNC:19253
OMIM 610877
CCDS CCDS56235
HPRD 11102
IMGT
EMBL AB014585 AK302472 AL096767 AL671545 AL954743 BC000976 BC006568 BC032664 BC041698 BC052995
GenPept AAH00976 AAH06568 AAH32664 AAH41698 AAH52995 BAA31660 BAH13719 CAO03456 CAO03457 CAO03458 CAO03459 CAO03561 CAO03562 CAO03563 CAO03564 CAO03642 CAO03643 CAO03644 CAO03645

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca