InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL4R

Summary

InnateDB Protein

IDBP-238894.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL4R

Protein Name

interleukin 4 receptor

Synonyms

CD124; IL-4RA; IL4RA;

Species

Homo sapiens

Ensembl Protein

ENSP00000379111

InnateDB Gene

IDBG-21808 (IL4R)

Protein Structure

UniProt Annotation

Function

Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. {ECO:0000269PubMed:8124718}.Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. {ECO:0000269PubMed:8124718}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 2 are highly expressed in activated T-cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	37 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0004913	interleukin-4 receptor activity
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding
GO:0043560	insulin receptor substrate binding

Biological Process

GO:0002532	production of molecular mediator involved in inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0019221	cytokine-mediated signaling pathway
GO:0030728	ovulation
GO:0035556	intracellular signal transduction
GO:0035771	interleukin-4-mediated signaling pathway
GO:0042127	regulation of cell proliferation
GO:0042832	defense response to protozoan
GO:0043032	positive regulation of macrophage activation
GO:0043627	response to estrogen
GO:0045087	innate immune response (InnateDB)
GO:0045626	negative regulation of T-helper 1 cell differentiation
GO:0045630	positive regulation of T-helper 2 cell differentiation
GO:0090197	positive regulation of chemokine secretion