InnateDB Protein
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IDBP-236715.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ING4
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Protein Name
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inhibitor of growth family, member 4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000380024
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InnateDB Gene
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IDBG-14716 (ING4)
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Protein Structure
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Function |
Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). {ECO:0000269PubMed:12750254, ECO:0000269PubMed:15029197, ECO:0000269PubMed:15251430, ECO:0000269PubMed:15528276, ECO:0000269PubMed:15897452, ECO:0000269PubMed:16387653}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:15029197, ECO:0000269PubMed:16973615}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
48
[view]
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Protein-Protein |
44
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001965
Zinc finger, PHD-type
IPR011011
Zinc finger, FYVE/PHD-type
IPR019787
Zinc finger, PHD-finger
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PFAM |
PF00628
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PRINTS |
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PIRSF |
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SMART |
SM00249
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UNL4
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PhosphoSite |
PhosphoSite-Q9UNL4
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TrEMBL |
R4GNG1
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UniProt Splice Variant |
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Entrez Gene |
51147
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UniGene |
Hs.524210
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RefSeq |
NP_001121054
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HUGO |
HGNC:19423
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OMIM |
608524
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CCDS |
CCDS44813
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HPRD |
09774
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IMGT |
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EMBL |
AB197695
AB197696
AB197697
AC125494
AC135892
AF063594
AF110645
AF156552
BC007781
BC013038
BC095434
CH471116
EF152349
EF152351
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GenPept |
AAD48585
AAG43153
AAH07781
AAH13038
AAH95434
AAL79773
ABO61139
ABO61141
BAF30477
BAF30478
BAF30479
EAW88763
EAW88768
EAW88770
EAW88772
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