InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACIN1

Summary

InnateDB Protein

IDBP-235563.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACIN1

Protein Name

apoptotic chromatin condensation inducer 1

Synonyms

ACINUS; ACN; fSAP152;

Species

Homo sapiens

Ensembl Protein

ENSP00000380502

InnateDB Gene

IDBG-3055 (ACIN1)

Protein Structure

UniProt Annotation

Function

Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence- independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269PubMed:10490026, ECO:0000269PubMed:12665594, ECO:0000269PubMed:18559500, ECO:0000269PubMed:22203037, ECO:0000269PubMed:22388736}.

Subcellular Localization

Nucleus. Nucleus speckle. Nucleus, nucleoplasm. Note=Phosphorylation on Ser-1180 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm.

Disease Associations

Tissue Specificity

Ubiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in patients with myeloid hematologic malignancies.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	93 [view]
Protein-Protein	92 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0016887	ATPase activity
GO:0019899	enzyme binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006397	mRNA processing
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0008380	RNA splicing
GO:0030218	erythrocyte differentiation
GO:0030263	apoptotic chromosome condensation
GO:0043065	positive regulation of apoptotic process
GO:0045657	positive regulation of monocyte differentiation
GO:0048025	negative regulation of mRNA splicing, via spliceosome

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016607	nuclear speck
GO:0035145	exon-exon junction complex
GO:0061574	ASAP complex