InnateDB Protein
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IDBP-235407.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CD151
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Protein Name
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CD151 molecule (Raph blood group)
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Synonyms
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GP27; MER2; PETA-3; RAPH; SFA1; TSPAN24;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000380566
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InnateDB Gene
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IDBG-18403 (CD151)
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Protein Structure
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Function |
Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. {ECO:0000269PubMed:15265795}.
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Subcellular Localization |
Membrane; Multi-pass membrane protein.
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Disease Associations |
Nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD) [MIM:609057]: A disorder characterized by the association of hereditary nephritis, epidermolysis bullosa, deafness, and beta-thalassemia minor. {ECO:0000269PubMed:15265795}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Expressed in a variety of tissues including vascular endothelium and epidermis. Expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes. {ECO:0000269PubMed:15265795}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000301
Tetraspanin
IPR008952
Tetraspanin, EC2 domain
IPR018499
Tetraspanin/Peripherin
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PFAM |
PF00335
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PRINTS |
PR00259
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PIRSF |
PIRSF002419
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P48509
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PhosphoSite |
PhosphoSite-P48509
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TrEMBL |
K4DIB7
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UniProt Splice Variant |
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Entrez Gene |
977
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UniGene |
Hs.654379
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RefSeq |
NP_620599
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HUGO |
HGNC:1630
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OMIM |
602243
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CCDS |
CCDS7719
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HPRD |
03763
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IMGT |
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EMBL |
AF315942
AK293073
AP006621
AP006623
BC001374
BC013302
BT007397
BT020132
CH471158
CR456826
CR542098
D29963
DQ074789
U14650
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GenPept |
AAA87064
AAH01374
AAH13302
AAK14179
AAP36061
AAV38934
AAY68211
BAA06229
BAF85762
CAG33107
CAG46895
EAX02400
EAX02402
EAX02406
EAX02407
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