InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BCR

Summary

InnateDB Protein

IDBP-2353.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCR

Protein Name

breakpoint cluster region

Synonyms

ALL; BCR1; CML; D22S11; D22S662; PHL;

Species

Homo sapiens

Ensembl Protein

ENSP00000352535

InnateDB Gene

IDBG-2349 (BCR)

Protein Structure

UniProt Annotation

Function

GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity. {ECO:0000269PubMed:1657398, ECO:0000269PubMed:1903516}.

Subcellular Localization

Disease Associations

Leukemia, chronic myeloid (CML) [MIM:608232]: A clonal myeloproliferative disorder of a pluripotent stem cell with a specific cytogenetic abnormality, the Philadelphia chromosome (Ph), involving myeloid, erythroid, megakaryocytic, B-lymphoid, and sometimes T-lymphoid cells, but not marrow fibroblasts. Note=The gene represented in this entry is involved in disease pathogenesis.Note=A chromosomal aberration involving BCR has been found in patients with chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	93 [view]
Protein-Protein	92 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0035023	regulation of Rho protein signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0016020	membrane
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000198 Rho GTPase-activating protein domain
IPR000219 Dbl homology (DH) domain
IPR001849 Pleckstrin homology domain
IPR008936 Rho GTPase activation protein
IPR015123 Bcr-Abl oncoprotein oligomerisation

PFAM

PF00168
PF00620
PF00621
PF00169
PF09036

PRINTS

PR00360

PIRSF

SMART

SM00239
SM00324
SM00325
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt