InnateDB Protein
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IDBP-235154.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EIF4ENIF1
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Protein Name
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eukaryotic translation initiation factor 4E nuclear import factor 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000380659
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InnateDB Gene
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IDBG-4689 (EIF4ENIF1)
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Protein Structure
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Function |
Nucleoplasmic shuttling protein. Mediates the nuclear import of EIF4E by a piggy-back mechanism.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:22090346}. Nucleus {ECO:0000269PubMed:22090346}. Nucleus, PML body {ECO:0000269PubMed:22090346}. Nucleus speckle {ECO:0000269PubMed:22090346}. Note=Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Localization to nuclear foci and speckles requires active transcription.
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Disease Associations |
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Tissue Specificity |
Widely expressed.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
24
[view]
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Protein-Protein |
21
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR018862
Eukaryotic translation initiation factor 4E transporter
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PFAM |
PF10477
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NRA8
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PhosphoSite |
PhosphoSite-Q9NRA8
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TrEMBL |
B1AKL6
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UniProt Splice Variant |
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Entrez Gene |
56478
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UniGene |
Hs.517559
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RefSeq |
NP_001157973
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HUGO |
HGNC:16687
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OMIM |
607445
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CCDS |
CCDS13898
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HPRD |
10456
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IMGT |
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EMBL |
AF240775
AK025254
AK074768
AK314636
AL096701
BC032941
BC033028
CH471095
CR456386
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GenPept |
AAF81693
AAH32941
AAH33028
BAB15092
BAC11194
BAG37198
CAG30272
EAW59977
EAW59978
EAW59979
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