InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: S100B

Summary

InnateDB Protein

IDBP-234904.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S100B

Protein Name

S100 calcium binding protein B

Synonyms

NEF; S100; S100-B; S100beta;

Species

Homo sapiens

Ensembl Protein

ENSP00000380769

InnateDB Gene

IDBG-6570 (S100B)

Protein Structure

UniProt Annotation

Function

Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. {ECO:0000269PubMed:20351179, ECO:0000269PubMed:22399290}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:9925766}. Nucleus {ECO:0000269PubMed:9925766}.

Disease Associations

Tissue Specificity

Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.

Experimentally validated
Total	38 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0044548	S100 protein binding
GO:0048156	tau protein binding
GO:0048306	calcium-dependent protein binding
GO:0050786	RAGE receptor binding

Biological Process

GO:0007409	axonogenesis
GO:0007417	central nervous system development
GO:0007611	learning or memory
GO:0008283	cell proliferation
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response

Cellular Component

GO:0001726	ruffle
GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm