InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KHSRP

Summary

InnateDB Protein

IDBP-233748.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KHSRP

Protein Name

KH-type splicing regulatory protein

Synonyms

FBP2; FUBP2; KSRP;

Species

Homo sapiens

Ensembl Protein

ENSP00000381216

InnateDB Gene

IDBG-21386 (KHSRP)

Protein Structure

UniProt Annotation

Function

Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single- stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'- UTR, possibly by recruiting degradation machinery to ARE- containing mRNAs. {ECO:0000250, ECO:0000269PubMed:11003644, ECO:0000269PubMed:8940189, ECO:0000269PubMed:9136930}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:19198587}. Cytoplasm {ECO:0000269PubMed:19198587}. Note=A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites. {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in neural and non-neural cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	86 [view]
Protein-Protein	71 [view]
Protein-DNA	4 [view]
Protein-RNA	11 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000375	RNA splicing, via transesterification reactions
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0006402	mRNA catabolic process
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051028	mRNA transport
GO:2000628	regulation of miRNA metabolic process