InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PIK3C3

Summary

InnateDB Protein

IDBP-232020.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIK3C3

Protein Name

phosphoinositide-3-kinase, class 3

Synonyms

hVps34; VPS34;

Species

Homo sapiens

Ensembl Protein

ENSP00000381845

InnateDB Gene

IDBG-2711 (PIK3C3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	50 [view]
Protein-Protein	47 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016303	1-phosphatidylinositol-3-kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0046854	phosphatidylinositol phosphorylation
GO:0048015	phosphatidylinositol-mediated signaling

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR002420 Phosphatidylinositol 3-kinase, C2 domain
IPR008290 Phosphatidylinositol 3-kinase, Vps34 type
IPR011009 Protein kinase-like domain
IPR016024 Armadillo-type fold

PFAM

PF00168
PF00454
PF00613
PF00792

PRINTS

PR00360

PIRSF

PIRSF000587

SMART

SM00239
SM00146
SM00145
SM00142

TIGRFAMs

Post-translational Modifications

Modification

Cross-References