InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MGRN1

Summary

InnateDB Protein

IDBP-230274.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MGRN1

Protein Name

mahogunin, ring finger 1

Synonyms

RNF156;

Species

Homo sapiens

Ensembl Protein

ENSP00000382487

InnateDB Gene

IDBG-12946 (MGRN1)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. {ECO:0000269PubMed:17229889, ECO:0000269PubMed:19703557, ECO:0000269PubMed:19737927}.

Subcellular Localization

Early endosome {ECO:0000269PubMed:17229889, ECO:0000269PubMed:19737927}. Note=The endosomal localization is dependent on the interaction with TSG101.Isoform 1: Cytoplasm, cytosol. Nucleus. Note=Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.Isoform 2: Cytoplasm, cytosol. Nucleus. Note=Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.Isoform 3: Cytoplasm, cytosol. Cell membrane.Isoform 4: Cytoplasm, cytosol. Cell membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0006513	protein monoubiquitination
GO:0008333	endosome to lysosome transport
GO:0043951	negative regulation of cAMP-mediated signaling
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome