InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRPV1

Summary

InnateDB Protein

IDBP-229784.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPV1

Protein Name

transient receptor potential cation channel, subfamily V, member 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000382659

InnateDB Gene

IDBG-17215 (TRPV1)

Protein Structure

UniProt Annotation

Function

Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Can be activated by endogenous compounds, including 12- hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (By similarity). Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. {ECO:0000250, ECO:0000269PubMed:11050376, ECO:0000269PubMed:11226139, ECO:0000269PubMed:11243859, ECO:0000269PubMed:12077606}.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, dendritic spine membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000269PubMed:12077606}; Multi-pass membrane protein {ECO:0000269PubMed:12077606}. Note=Mostly, but not exclusively expressed in postsynaptic dendritic spines. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level). {ECO:0000269PubMed:11050376, ECO:0000269PubMed:11243859, ECO:0000269PubMed:14987252}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005216	ion channel activity
GO:0005231	excitatory extracellular ligand-gated ion channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0015278	calcium-release channel activity
GO:0051219	phosphoprotein binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0007166	cell surface receptor signaling pathway
GO:0007635	chemosensory behavior
GO:0034220	ion transmembrane transport
GO:0050955	thermoception
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0071312	cellular response to alkaloid
GO:0071318	cellular response to ATP

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0031226	intrinsic component of plasma membrane
GO:0032591	dendritic spine membrane
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002110 Ankyrin repeat
IPR004729 Transient receptor potential channel
IPR008347 Transient receptor potential channel, vanilloid 1-4
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00023
PF13606
PF11929
PF12796

PRINTS

PR01415
PR01768

PIRSF

SMART

SM00248

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt