InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLDN8

Summary

InnateDB Protein

IDBP-229510.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLDN8

Protein Name

claudin 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000382783

InnateDB Gene

IDBG-1429 (CLDN8)

Protein Structure

UniProt Annotation

Function

Plays a major role in tight junction-specific obliteration of the intercellular space. {ECO:0000250}.

Subcellular Localization

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Localizes to tight junctions in all 3 segments of the epididymis, in the caput found in the lateral margins of principal cells, and in the corpus at the interface between basal and principal cells.

Disease Associations

Tissue Specificity

Expressed in the epididymis, mainly in the caput segment. {ECO:0000269PubMed:17287494}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0016338

calcium-independent cell-cell adhesion

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane