Version 5.4
Homo sapiens Protein: MYL12B
Summary
InnateDB Protein IDBP-228859.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYL12B
Protein Name myosin, light chain 12B, regulatory
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000383037
InnateDB Gene IDBG-455 (MYL12B)
Protein Structure
UniProt Annotation
Function Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Ubiquitously expressed in various hematopoietic cells. {ECO:0000269PubMed:11436981, ECO:0000269PubMed:18480596}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0006936 muscle contraction
GO:0007411 axon guidance
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002048 EF-hand domain
PFAM PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O14950
PhosphoSite PhosphoSite-O14950
TrEMBL
UniProt Splice Variant
Entrez Gene 103910
UniGene Hs.594402
RefSeq NP_001138416
HUGO HGNC:29827
OMIM 609211
CCDS CCDS11831
HPRD 10095
IMGT
EMBL AB046614 AK291726 AY320408 BC004994 CH471113 D50372 D82058 U26162
GenPept AAA67367 AAH04994 AAP73808 BAA23323 BAB62403 BAB88918 BAF84415 EAX01675 EAX01676 EAX01677

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca