InnateDB Protein
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IDBP-228819.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NRIP1
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Protein Name
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nuclear receptor interacting protein 1
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Synonyms
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RIP140;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000383060
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InnateDB Gene
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IDBG-788 (NRIP1)
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Protein Structure
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Function |
Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. {ECO:0000269PubMed:10364267, ECO:0000269PubMed:11509661, ECO:0000269PubMed:11518808, ECO:0000269PubMed:12554755, ECO:0000269PubMed:15060175, ECO:0000269PubMed:7641693}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:11266503, ECO:0000269PubMed:12773562, ECO:0000269PubMed:15060175, ECO:0000269PubMed:7641693}. Note=Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand- bound NR3C1.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated |
Total |
85
[view]
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Protein-Protein |
80
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
12 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006351
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transcription, DNA-templated
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GO:0030521
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androgen receptor signaling pathway
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GO:0045087
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innate immune response (InnateDB)
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P48552
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PhosphoSite |
PhosphoSite-P48552
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TrEMBL |
N0GWB6
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UniProt Splice Variant |
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Entrez Gene |
8204
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UniGene |
Hs.644641
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RefSeq |
XP_005261120
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HUGO |
HGNC:8001
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OMIM |
602490
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CCDS |
CCDS13568
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HPRD |
03927
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IMGT |
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EMBL |
AF127577
AF248484
AL163207
BC040361
HF584749
HF584750
X84373
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GenPept |
AAF35255
AAF62185
AAH40361
CAA59108
CAB90396
CCQ44046
CCQ44047
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