Version 5.4
Homo sapiens Protein: MOB1B
Summary
InnateDB Protein IDBP-22809.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MOB1B
Protein Name MOB kinase activator 1B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000310189
InnateDB Gene IDBG-22807 (MOB1B)
Protein Structure
UniProt Annotation
Function Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. {ECO:0000269PubMed:15067004, ECO:0000269PubMed:19739119}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:15067004}. Nucleus {ECO:0000269PubMed:15067004}.
Disease Associations
Tissue Specificity Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver. {ECO:0000269PubMed:19739119}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
Experimentally validated
Total 47 [view]
Protein-Protein 47 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019209 kinase activator activity
GO:0019900 kinase binding
GO:0046872 metal ion binding
Biological Process
GO:0035329 hippo signaling
GO:0042327 positive regulation of phosphorylation
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR005301 Mob1/phocein
PFAM PF03637
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7L9L4
PhosphoSite PhosphoSite-Q7L9L4
TrEMBL Q4W5E0
UniProt Splice Variant
Entrez Gene 92597
UniGene Hs.741364
RefSeq NP_775739
HUGO HGNC:29801
OMIM 609282
CCDS CCDS34002
HPRD 17582
IMGT
EMBL AC021989 AC093851 AC108014 AJ577473 AK299481 AK313513 BC038112 CH471057
GenPept AAH38112 AAY41047 BAG36293 BAG61445 CAE12091 EAX05636

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca