InnateDB Protein
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IDBP-22677.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SIVA1
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Protein Name
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SIVA1, apoptosis-inducing factor
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Synonyms
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CD27BP; SIVA; Siva-1; Siva-2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000329447
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InnateDB Gene
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IDBG-22673 (SIVA1)
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Protein Structure
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Function |
Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa- B and promotes T-cell receptor-mediated apoptosis. {ECO:0000269PubMed:12011449, ECO:0000269PubMed:14739602, ECO:0000269PubMed:15034012, ECO:0000269PubMed:15958577, ECO:0000269PubMed:16491128}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:15034012}. Nucleus {ECO:0000269PubMed:15034012}. Note=In the nucleus, accumulates in dot-like structures.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
27
[view]
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Protein-Protein |
27
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006924
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activation-induced cell death of T cells
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GO:0009615
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response to virus
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GO:0016032
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viral process
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GO:0032088
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negative regulation of NF-kappaB transcription factor activity
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GO:0045087
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innate immune response (InnateDB)
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GO:0097191
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extrinsic apoptotic signaling pathway
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GO:0097193
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intrinsic apoptotic signaling pathway
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GO:1901030
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positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR022773
Siva
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PFAM |
PF05458
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PRINTS |
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PIRSF |
PIRSF038096
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O15304
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PhosphoSite |
PhosphoSite-O15304
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
10572
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UniGene |
Hs.112058
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RefSeq |
NP_068355
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HUGO |
HGNC:17712
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OMIM |
605567
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CCDS |
CCDS9993
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HPRD |
16124
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IMGT |
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EMBL |
AF033111
AF401214
BC034562
BK000018
U82938
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GenPept |
AAC51372
AAD50057
AAH34562
AAL02171
DAA01049
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