InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLCO1B1

Summary

InnateDB Protein

IDBP-22551.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLCO1B1

Protein Name

solute carrier organic anion transporter family, member 1B1

Synonyms

HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2; OATPC; SLC21A6;

Species

Homo sapiens

Ensembl Protein

ENSP00000256958

InnateDB Gene

IDBG-22549 (SLCO1B1)

Protein Structure

UniProt Annotation

Function

Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver. {ECO:0000269PubMed:10358072, ECO:0000269PubMed:10601278, ECO:0000269PubMed:12196548, ECO:0000269PubMed:22232210}.

Subcellular Localization

Basolateral cell membrane {ECO:0000269PubMed:12196548}; Multi-pass membrane protein {ECO:0000269PubMed:12196548}. Note=Detected in basolateral membranes of hepatocytes.

Disease Associations

Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. {ECO:0000269PubMed:22232210}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte. {ECO:0000269PubMed:10358072, ECO:0000269PubMed:10601278, ECO:0000269PubMed:22232210}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0015347	sodium-independent organic anion transmembrane transporter activity

Biological Process

GO:0006810	transport
GO:0008206	bile acid metabolic process
GO:0015711	organic anion transport
GO:0015721	bile acid and bile salt transport
GO:0043252	sodium-independent organic anion transport
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002350 Kazal domain
IPR004156 Organic anion transporter polypeptide OATP
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00050
PF07648
PF03137
PF07690

PRINTS

PIRSF

SMART

SM00280

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y6L6