InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDE3A

Summary

InnateDB Protein

IDBP-22317.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE3A

Protein Name

phosphodiesterase 3A, cGMP-inhibited

Synonyms

CGI-PDE; CGI-PDE A; CGI-PDE-A;

Species

Homo sapiens

Ensembl Protein

ENSP00000351957

InnateDB Gene

IDBG-22315 (PDE3A)

Protein Structure

UniProt Annotation

Function

Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0004119	cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
GO:0030552	cAMP binding
GO:0046872	metal ion binding

Biological Process

GO:0001556	oocyte maturation
GO:0006198	cAMP catabolic process
GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0016101	diterpenoid metabolic process
GO:0019933	cAMP-mediated signaling
GO:0019934	cGMP-mediated signaling
GO:0040020	regulation of meiosis
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043116	negative regulation of vascular permeability
GO:0043117	positive regulation of vascular permeability
GO:0051591	response to cAMP
GO:0060282	positive regulation of oocyte development
GO:0071321	cellular response to cGMP
GO:0071560	cellular response to transforming growth factor beta stimulus